- Researchers from Cornell Medical College report that mass spectrometry (which is a tool commonly used to identify lipids and proteins by weighing individual molecules) can for the first time ever give scientists insight into how antibiotics work inside living cells to kill microbes.
- This new application of mass spectrometry can enhance our ability to develop more effective and less drug-resistant antibiotics.
- The need for new antibiotics is a particularly pressing need for those seeking treatment for tuberculosis (TB), which is the single leading bacterial cause of death in the world and has become drug-resistant.
- Mass spectrometry studies performed with two TB drugs para-amino-salicylic acid (PAS) and sulfonamide (sulfa) produced unexpected results that “show us that sometimes there is a profound disconnect between what we think a drug is doing and how it actually works inside cells,” according to Dr. Kyu Y. Rhee. (details of study available through source link below)